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Astrion

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Astrion

Skin rejuvenation and hydration through enhanced
endogenous production of collagen & hyaluronic acid


Astrion™ is a clinically-studied cosmeceutical composed of highly purified and fractionated extracts from Astragalus membranaceous and Centella asiatica produced by a proprietary extraction method.

Applications: Water soluble for topical and oral intake

12 in-vitro and 1 human clinical trial

Patents:
US 7,959,952
TW I362936
CN 2007 10095863


BENEFITS
 

Astrion™ reduces the number and appearance of fine lines and wrinkles through increased endogenous production of collagen and hyaluronic acid as well as increased production of proline and glucosamine (the building blocks of collagen and hyaluronic acid, respectively) in skins cells, Astrion™ also reduces the breakdown of collagen in skin cells and skin discoloration due to UV light damage from the sun.

Specifically, Astrion™ has shown in 12 in-vitro and one human study to:

  • increase collagen I synthesis in epidermal cells (HaCaT cell) by 60%
  • increase collagen I synthesis in dermal cells (HDF cell) by 80%
  • increase collagen I secretion in dermal cells (HDF cell) by 45%
  • increase collagen III synthesis in dermal cells (HDF cell) by 30%
  • increase collagen III secretion in dermal cells (HDF cell) by 80%
  • increase hyaluronic acid synthesis in epidermal cells (HaCaT cell) by 20%
  • increase the hyaluronic acid synthase (HA Synthase 2) gene expression in epidermal cells (HaCaT cell) by 30%
  • increase proline uptake in epidermal cells (HaCaT cell) by 27%
  • increase glucosamine uptake in epidermal cells (HaCaT cell) by 11%
  • increase telomerase activity in epidermal cells (HaCaT cell) by 265%
  • decrease MMP-1 protein synthesis in dermal cells (HDF cell) by 51%
  • decrease MMP-1 gene expression in dermal cells (HDF cell) by 50%
  • reduce wrinkles by 15% (human study)
  • reduces melanin by 17% for lightening up the skin (human study)